Principal Research Scientist I (all genders) Medicinal Chemistry (permanent / full-time)

Company: Allergan
Location: Lincoln
Posted on: June 1, 2025

Job Description:

Principal Research Scientist I (all genders) Medicinal Chemistry (permanent / full-time)AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas - immunology, oncology, neuroscience, and eye care - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at . Follow @abbvie on , , , and .The job that makes possibilities real in patients' lives. And yours.The job that helps you get ahead in life. Moving mountains together.Welcome to AbbVie! As part of an international company with 48,000 employees worldwide and around 3,000 employees in Germany, you will have the opportunity of addressing some of tomorrow's unmet medical needs in close collaboration with your colleagues. Are you passionate about improving global health care? Do you want to contribute to improving patients' quality of life through your expertise? In a challenging work environment that offers opportunities of developing and increasing your own skills? You've come to the right place!Moving mountains together - as Principal Research Scientist I (all genders) Medicinal Chemistry (permanent / full-time)Small Molecular Therapeutics and Platform Technologies (SMTPT) within Discovery Research in Ludwigshafen (Germany) seeks an accomplished scientist to lead a team of medicinal chemists within the Global Medicinal Chemistry (GMEC) organization. GMEC is committed to delivering first and best-in-class small molecules in conventional and unconventional drug-like space with the potential to improve human health. The Principal Research Scientist will lead a team of chemists designing and synthesizing small molecules aimed at identifying and advancing promising low dose leads.They will be responsible for managing a diverse team of scientists who design and synthesize drug candidates for novel targets throughout AbbVie's drug discovery pipeline and may serve as Medicinal Chemistry Lead for some of these efforts. The candidate will have a strong background in synthetic chemistry and have demonstrated high productivity in synthesizing complex organic molecules. The team will develop novel medicinal chemistry strategies and execute multiparametric optimization(s) of drug candidate properties in a highly collaborative environment aimed at accelerating the delivery of a sustainable pipeline of first in class/breakthrough small molecule drug candidates with transformative potential.The candidate will have experience with strategic planning, and leadership of medicinal chemistry teams as well as working with cross-functional teams. The candidate will have a strong expertise in modern medicinal chemistry, including an appreciation of modern computational and experimental tools, multidisciplinary inputs, and synthetic technologies needed to develop low dose small molecule drug candidates. The ideal candidate will be able to lead by influence in a matrix environment and maintain a productive, collaborative, and inclusive environment. Strong communication skills are essential as the candidate must be able to tailor interactions with technical teams and represent the medicinal chemistry advances to AbbVie leadership.Responsibilities

• Lead international Medicinal Chemistry teams and partner cross-functionally to advance projects by applying state-of-the-art methodologies in drug discovery.
• Lead internal Medicinal Chemistry teams and/or steer teams at our CRO partners in the design and synthesis of low dose drug candidates and the development of stage-appropriate progression funnels for their identification from research to development.
• As programs advance, work with key stakeholders in the Development sciences core team to address and reduce risks in collaboration to drive towards candidate nomination.
• Lead chemistry team activities and maintain a high level of productivity in the laboratory setting.
• Promote professional development of a team of scientists through effective mentoring, guidance, and supervision.
• Identify and integrate emerging scientific trends from internal and external sources into functional objectives.
• Present program updates and research strategies to functional and non-functional leaders as well as potential and existing partners.
• Maintain awareness of emerging literature and science in the field and author scientific disclosures/publications.
• Maintain scientific presence outside AbbVie with appropriate publication and conference abstract submission highlighting innovative medicinal chemistry learnings.
• A mix of on-site and remote working will be possible in alignment with the role responsibilities.
• PhD with typically 6+ years of experience in organic or medicinal chemistry or equivalent field with 6+ years of relevant work experience in biotech or pharma. BS or equivalent education and extensive, typically 14+ years of experience; MS or equivalent education with typically 12+ years of experience.
• Extensive knowledge and experience in modern medicinal chemistry, preferably also in the field of protein degradation and CNS-drug development.
• Highly organized and self-directed, experience leading medicinal chemistry teams.
• Proven track record of productivity in the laboratory setting.
• Excellent written and verbal communication is required as well as critical evaluation and data-driven decision making.
• Highly collaborative, team-oriented, and considerate of the needs of others.
• Strong interpersonal skills and ability to collaborate with diverse groups within the organization and external partners.
• Proven chemistry team leadership and management abilities, including experience mentoring, guiding, supervising, and developing early career chemists.
• Ability to create an inclusive environment where diverse ideas, viewpoints and backgrounds are valued; willingness and ability to lead inclusively and demonstrate a commitment to listen and consider all points of view.Here's how we can move mountains together
  • With a diverse work environment where you can have a real impact.
  • With an open corporate culture.
  • With an attractive salary.
  • With an intensive onboarding process with a mentor at your side.
  • With flexible work models for a healthy work-life balance.
  • With a corporate health management that offers comprehensive health and exercise programs.
  • With company social benefits.
  • With a wide range of career opportunities in an international organization.
  • With top-tier, attractive development opportunities.
  • With a strong international network.Multiple times, we have been globally recognized as a "Great Place to Work" and we are proud to provide our employees with the flexibility to maintain a healthy work-life balance. We take our impact on the environment and our communities seriously and therefore focus on giving something back on a regular basis. We are committed to equality, equity, diversity and inclusion (EED&I) - a commitment that is fundamental to us. This includes appreciating different perspectives, creating an inclusive culture and treating all employees with dignity and respect.At AbbVie, your individual contributions count - help us move mountains together. Be a part of our success, grow with us and accomplish more than you could have imagined. Sounds like the perfect career opportunity for you? We look forward to receiving your application! All you need is a complete CV - we will discuss everything else with you in person.Any questions? Feel free to email us at - we look forward to hearing from you!
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Keywords: Allergan, Grand Island , Principal Research Scientist I (all genders) Medicinal Chemistry (permanent / full-time), Other , Lincoln, Nebraska